三维适形放疗联合替莫唑胺治疗恶性脑胶质瘤的临床研究

目的：研究恶性脑胶质瘤术后三维适行放疗联合替莫唑胺的有效性和安全性。方法：选择我院收治11例术后病例证实为恶性脑胶质瘤患者,行三维适行放疗,180cGy-200cGy/次,1次/天,5天/周,DT50Gy-68Gy,同时采用替莫唑胺化疗。结果：本组患者CR为54.5%,PR为27.3%,SD为9.1%,PD为9.1%,有效率为81.8%（9/11）,1a,2a和3a生存率分别为63.6%、27.3%和18.2%,毒副反应较轻,均可以耐受。结论：三维适行放疗联合替莫唑胺治疗术后恶性脑胶质瘤近期疗效较好,耐受性良好且安全性较高。

A Clinical Study of Three-dimensional Conformal Radiotherapy with Temozolomide in Treatment of Postoperative Malignant Glinoma

Objective： To study the efficacy and security of three-dimensional conformal radiotherapy concomitant with temozolo- mide in patients with postoperative malignant glinoma. Methods： Eleven patients with pathologically confirmed malignant glinoma were treated by 3D-CRT atter operation with a dose of 50-68Gy and concomitant temozolomide chemotherapy fi＇om Mar. 2003 to Mar. 2006. Results： The overall response rates were 81.8%, including six （54.5%） patients with complete responses, three （27.3%） patients with partial responses, one （9.1%） patients with stable disease and one （9.1%） patients with progressive disease. One, two and three years suvival rates were 63.6%, 27.3% and 18.2%, respectively. Conclusions： Three-dimensional conformal radiotherapy concomitant with temozolo- mide is effective, good tolerance and safety in the treatment of postoperative malignant glinoma.