哈萨克族原发性高血压患者血浆EPCs CD34^＋水平及其相关性研究

目的：探讨血浆内皮祖细胞（EPCs） CD34＋水平与新疆哈萨克族（哈族）原发性高血压病患者血压、血脂、血糖、肥胖等的相关性。方法：选取新疆哈族原发性高血压患者87为观察组,哈族健康对照组79例,测量血压（BP）、身高、体重、腰围（WC）、臀围（HC）,抽取空腹静脉血测定血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）,计算体重指数（BMI）腰臀比（WHR）。结果：①原发性高血压组血浆EPCs CD34^＋水平明显低于对照组（p〈0.01）②原发性高血压组血浆EPCs CD34^＋水平与收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、血糖、体重指数呈显著负相关。对照组血浆EPCsCD34^＋水平与收缩压、舒张压、总胆固醇、甘油三酯、体重指数呈负相关。③多元回归分析显示在原发性高血压组中收缩压、甘油三酯是影响血浆EPCs CD34^＋水平的独立因素,在对照组中总胆固醇、体重指数是影响血浆EPCs CD34^＋水平水平的独立因素。结论：哈族原发性高血压患者血浆EPCs CD34^＋水平与血压水平存在一定的相关性。

Plasma EPCs CD34^＋ level and its correlation in patients with essential hypertension of Kazakans

Objective： To investigate the relationship between plasma endothelial progenitor cells （EPCs）CD34 levels and blood pressure blood lipid blood glucose and obesity of the patients with essential hypertension （EH）of Xinjiang Kazakans. Methods： Totally 166 Kazakans were selected for the subjects. They were divided into two groups according to their blood pressure： EH groups （n=87） and control group （ n=79 ）. Measurement of blood pressure, body height body mass waist circumference and hip. Fasting venous blood was drawn to detect the plasma EPCs CD34^＋ level, fasting plasma glucose （FPG）, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, calculating body mass index, waist-hip ratio （WHR）. Results： ① the Plasma EPCs CD34^＋ level in essential hypertension group was significantly lower than that in control group （p〈0.01）.②Plasma EPCs CD34^＋ level was negatively and signficantly correlated with SBP, DBP, TC, TG, LDL-C, FPG, BMI in EH group. And negatively and signficantly correlated with SBP, DBP, TC, TG, WHR, BMI in control group.③ Multiple regression analysis showed that SBP and TG were independent factors to affect the Plasma EPCsCD34^＋ level in EH,TC and BMI were independent factors to affect the Plasma EPCs CD34^＋ level in control group. Conclusions： Plasma EPCs CD34^＋ level is related to blood pressure in patients with essential hypertension ofxinjing Kazakans.