| 整联蛋白与口蹄疫病毒感染 |
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| 引用本文： | 祝秀梅,慕洪涛,王凡,吕志慧,马全英,刘学荣,黄银君,黄安仓,牟克斌.整联蛋白与口蹄疫病毒感染[J].生物磁学,2009(15):2986-2988. |
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| 作者姓名： | 祝秀梅 慕洪涛 王凡 吕志慧 马全英 刘学荣 黄银君 黄安仓 牟克斌 |
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| 作者单位： | [1]中农威特生物科技股份有限公司,甘肃兰州730046 [2]甘肃省庆阳市动物卫生监督所,甘肃庆阳745000 |
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| 摘 要： | 整联蛋白是一类重要的细胞表面分子,除介导细胞与胞外基质及细胞间的粘附外,还对细胞的识别、生长和分化具有重要作用。FMDV对细胞的侵染依赖于宿主细胞受体,整联蛋白作为口蹄疫病毒侵入细胞的关键决定簇,在致病机制、组织和器官嗜性中具有重要作用。本文就整联蛋白的结构、功能及在FMDV感染中的作用等方面进行了综述,以期阐明FMDV侵染细胞的机制。
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| 关 键 词： | 整联蛋白 FMDV 细胞受体 介导感染 |
Integrin and Foot-and-mouth Disease Virus Infection |
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| ZHU Xiu-mei,MU Hong-tao,WANG Fan,LV Zhi-hui,MA Quan-ying,LIU Xue-rong,HUANG Yin-jun,HUANG An-cang,MU Ke-bin.Integrin and Foot-and-mouth Disease Virus Infection[J].Biomagnetism,2009(15):2986-2988. |
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| Authors: | ZHU Xiu-mei MU Hong-tao WANG Fan LV Zhi-hui MA Quan-ying LIU Xue-rong HUANG Yin-jun HUANG An-cang MU Ke-bin |
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| Institution: | 1 China Agricultural Veterinary Biological Science and Technology Co;Ltd, Gansu, 730046, China; 2 Animal Health Authority, Gansu, Qingyang, 745000, China) |
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| Abstract: | Integrins are an important cell surface molecules that contribute to a variety of biological functions, including mediate celt and extracellular matrix and cell-cell adhesion. In addition, integrins also play the important roles in indentification of cells, growth and differentiation. FMDV infected cells depends on host cell receptors. They play the important roles in pathogenesis mechanism, tissue and host tropism as key determinant in FMDV infected host cells. This article is mainly about the structure, function and roles of FMDV infection in order to clarify the mechanism of FMDV infected cells. |
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| Keywords: | integrin foot-and-mouth disease cell receptors mediated infection |
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