Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors |
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| Authors: | Elayadi Hanane Smietana Michael Pannecouque Christophe Leyssen Pieter Neyts Johan Vasseur Jean-Jacques Lazrek Hassan B |
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| Affiliation: | Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Université Montpellier II, Montpellier, France. |
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| Abstract: | ![]()
Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies. |
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