Characterization of the mrgRS locus of the opportunistic pathogen Burkholderia pseudomallei: temperature regulates the expression of a two-component signal transduction system |
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| Authors: | Magdy E Mahfouz T Hilton Grayson David AB Dance Martyn L Gilpin |
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| Affiliation: | (1) Department of Biological and Geological Sciences, Faculty of Education, Kafr ElSheikh, Tanta University, Egypt;(2) School of Biological Sciences, University of Plymouth, England, UK;(3) Health Protection Agency South West, Derriford, Plymouth, England, UK |
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| Abstract: | Background Burkholderia pseudomallei is a saprophyte in tropical environments and an opportunistic human pathogen. This versatility requires a sensing mechanism that allows the bacterium to respond rapidly to altered environmental conditions. We characterized a two-component signal transduction locus from B. pseudomallei 204, mrgR and mrgS, encoding products with extensive homology with response regulators and histidine protein kinases of Escherichia coli, Bordetella pertussis, and Vibrio cholerae. |
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