High yield expression of leptospirosis vaccine candidates LigA and LipL32 in the methylotrophic yeast Pichia pastoris |
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| Authors: | Daiane D Hartwig Thaís L Oliveira Fabiana K Seixas Karine M Forster Caroline Rizzi Cláudia P Hartleben Alan JA McBride Odir A Dellagostin |
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| Affiliation: | 1.Núcleo de Biotecnologia,Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas,Pelotas,Brazil;2.Laboratório de Patologia e Biologia Molecular,Instituto Gon?alo Moniz,Salvador,Brazil |
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| Abstract: | Background Leptospirosis, a zoonosis caused by Leptospira spp., is recognized as an emergent infectious disease. Due to the lack of adequate diagnostic tools, vaccines are an attractive intervention strategy. Recombinant proteins produced in Escherichia coli have demonstrated promising results, albeit with variable efficacy. Pichia pastoris is an alternative host with several advantages for the production of recombinant proteins. |
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