P2 receptors and immunity |
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| Authors: | Amel Rayah Jean M Kanellopoulos Francesco Di Virgilio |
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| Institution: | 1. Department of Intensive Care, Hôpital Raymond Poincaré (APHP), Laboratory of Infection & Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University Paris Saclay, INSERM, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), RHU RECORDS (Rapid rEcognition of CORticosteroiD resistant or sensitive Sepsis), 104 Boulevard Raymond Poincaré, Garches 92380, France;2. Clinical Research Unit AP-HP, Paris-Saclay, H^opital Raymond Poincar_e, School of Medicine Simone Veil, University Versailles Saint Quentin, University Paris, Saclay, INSERM, CESP Anti-Infective Evasion and Pharmacoepidemiology Team, F-78180 Montigny-Le-Bretonneux, France;3. Laboratory of Immunology, Georges-Pompidou European Hospital (APHP), Invasive Bacterial Infection Unit and National Reference Center for Meningococci, Pasteur, Institute, Centre de Recherche des Cordeliers, Paris, France |
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| Abstract: | Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release, phagocytosis, Ag presentation and cytotoxicity. This makes P2 receptors an attractive target for the therapy of immuno-mediated disease and cancer. |
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