Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs) |
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| Authors: | Darren A Natale Uma T Shankavaram Michael Y Galperin Yuri I Wolf L Aravind Eugene V Koonin |
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| Institution: | (1) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rockville Pike, Bethesda, MD 20894, USA; |
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| Abstract: | Background Standard archival sequence databases have not been designed as tools for genome annotation and are far from being optimal
for this purpose. We used the database of Clusters of Orthologous Groups of proteins (COGs) to reannotate the genomes of two
archaea, Aeropyrum pernix, the first member of the Crenarchaea to be sequenced, and Pyrococcus abyssi. |
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