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A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations
Authors:Ason C.-Y. Chiang,Eleanor McCartney,Patrick H. O&#x  Farrell,Hansong Ma
Affiliation:1. Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK;2. Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK;3. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:
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  • Keywords:Corresponding author  mito-nuclear interaction  mitochondrial DNA heteroplasmy  mtDNA polymerase gamma  mtDNA competition  mtDNA transmission and inheritance
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