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Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
Authors:Anna KL Liess  Alena Kucerova  Kristian Schweimer  Lu Yu  Theodoros I Roumeliotis  Mathias Diebold  Olexandr Dybkov  Christoph Sotriffer  Henning Urlaub  Jyoti S Choudhary  Jörg Mansfeld  Sonja Lorenz
Institution:1. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany;2. Cell Cycle, Biotechnology Center, Technische Universität Dresden, 01307 Dresden, Germany;3. Biopolymers, University of Bayreuth, 95447 Bayreuth, Germany;4. Functional Proteomics Group, The Institute of Cancer Research, London SW3 6JB, UK;5. Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany;6. Department for Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, 37077 Göttingen, Germany;7. Group for Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry, Göttingen, 37077 Göttingen, Germany;8. Proteomics Service Facility, Georg-August-Universität, Göttingen, 37077 Göttingen, Germany
Abstract:
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  • Keywords:Corresponding author  E2 enzyme  ubiquitin  mitosis  enzyme mechanism  NMR  X-ray crystallography  molecular dynamics  mass spectrometry  cell cycle  K11 chain
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