Alcohol Consumption and the Neoplastic Progression in Barrett's Esophagus: A Systematic Review and Meta-Analysis |
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| Authors: | Zhifeng Lou Haibo Xing Da Li |
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| Affiliation: | 1. The department of stomatology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.; 2. The department of intensive care unit, Xiasha Hospital, Hangzhou, Zhejiang, P. R. China.; 3. Department of Medical Oncology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.; Shiga University of Medical science, Japan, |
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| Abstract: | PurposeIn the developed countries, the incidence of esophageal adenocarcinoma (EAC) is increasing over recent decades. The purpose of this meta-analysis was to arrive at quantitative conclusions about the contribution of alcohol intakes and the progression of Barrett''s esophagus.MethodsA comprehensive, systematic bibliographic search of medical literature published up to Oct 2013 was conducted to identify relevant studies. A meta-analysis was conducted for alcohol consumption on the Barrett''s esophagus progression.ResultsA total of 882 cases in 6,867 individuals from 14 observational studies were indemnified in this meta-analysis. The result of this current meta-analysis, including 10 case-control and 4 cohort studies, indicated that alcohol consumption was not associated with the neoplastic progression in Barrett''s esophagus (RR, 1.17; 95% CI, 0.93–1.48). When stratified by the study designs, no significant association was detected in either high vs low group or ever vs never group.ConclusionsAlcohol drinking is not associated with risk of neoplastic progression in Barrett''s esophagus. Further well designed studies are needed in this area. |
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