Molecular and cellular characterization of transferrin receptor 2 |
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Authors: | Subramaniam V Nathan Summerville Lesa Wallace Daniel F |
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Institution: | (1) Membrane Transport Laboratory, Queensland Institute of Medical Research, 4006 Brisbane, QLD, Australia;(2) University of Queensland, 4072 Brisbane, QLD, Australia |
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Abstract: | Iron is an essential component of many biological processes. However, an excess of iron in the body is also toxic; thus, the
levels of this element are tightly regulated. Our knowledge of the mechanism by which iron levels are maintained has been
bolstered by the dramatic increase in the discovery of novel molecules implicated in iron homeostasis. The transferrin receptor-transferrin
pathway is the main mechanism by which cells take up iron. The recently identified homolog of transferrin receptor, its characterization
and its role in iron metabolism is the subject of this review. |
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Keywords: | Iron transport liver transferrin receptor hemochromatosis HFE |
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