Phytanic acid alpha-oxidation in human cultured skin fibroblasts. |
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| Authors: | I Singh O Lazo P Kalipada A K Singh |
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| Affiliation: | Department of Pediatrics, Medical University of South Carolina, Charleston 29425. |
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| Abstract: | We studied the oxidation of [1-14C]phytanic acid, 3-methyl substituted fatty acid, to pristanic acid and 14CO2 in human skin fibroblasts. The specific activity for alpha-oxidation of phytanic acid in peroxisomes was 29- and 124-fold higher than mitochondria and endoplasmic reticulum. This finding demonstrates for the first time the presence of fatty acid alpha-oxidation enzyme system in peroxisomes. |
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