Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy

Authors:	Sebastian Brachtendorf Ruth Anna Wanger Kerstin Birod Dominique Thomas Sandra Trautmann Marthe-Susanna Wegner Dominik C. Fuhrmann Bernhard Brüne Gerd Geisslinger Sabine Grösch

Affiliation:	1. Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, Germany;2. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology (TMP), Frankfurt, Germany;3. Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany

Abstract:

Keywords:	3′-UTR three prime untranslated region 5-FU 5-fluorouracil ANOVA analysis of variance AP-1 activator protein 1 AUC area under the curve Cer ceramide CerS ceramide synthase CoA coenzyme A CQ chloroquine CREB cAMP response element-binding protein CRE-BP CREB binding protein dhCer dihydroceramide DSS dextran sulfate sodium DTT dithiothreitol EMD emerin EV empty vector ECAR extracellular acidification rate FB1 fumonisin B1 GFP green fluorescent protein GluCer, GlcCer glucosylceramide GW4869 LacCer lactosylceramide LC3B microtubule-associated proteins 1A/1B light chain 3B LC-MS/MS liquid chromatography coupled to tandem mass spectrometry LUC luciferase miR, miRNA microRNA MMP-1 matrix metalloproteinase-1 NC negative control nSMase neutral sphingomyelinase OCR oxygen consumption rate Ox. oxaliplatin PI propidium iodide Poly(A) polyadenylation qRT-PCR quantitative real-time polymerase chain reaction RPL37A 60S ribosomal protein L37a S1P sphingosine-1-phosphate SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis SEM standard error of the mean shRNA short hairpin RNA SP1 specificity protein 1 Untr. untreated WST water-soluble tetrazolium Sphingolipid Chemoresistance shRNA Oxaliplatin 5-Fluorouracil
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