| 细胞衰老与衰老细胞 |
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| 引用本文： | 王璞,陈露萍,李清泉,汤奇胜,沈亦雯,朱剑虹.细胞衰老与衰老细胞[J].生物化学与生物物理进展,2012,39(3):257-263. |
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| 作者姓名： | 王璞 陈露萍 李清泉 汤奇胜 沈亦雯 朱剑虹 |
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| 作者单位： | 复旦大学附属华山医院;复旦大学附属华山医院;复旦大学上海医学院;复旦大学附属华山医院;复旦大学附属华山医院;复旦大学附属华山医院神经外科，医学神经生物学国家重点实验室，复旦大学脑科学研究院，复旦大学上海医学院 |
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| 基金项目： | 国家重点基础研究发展计划(973)(2010CB945504, 2012CB966300, 2009CB941100)，国家自然科学基金(30870805, 90919002)和上海市科委基础研究重点项目(08dj1400503)资助 |
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| 摘 要： | 细胞衰老(cellular senescence)是一个应激导致细胞生长停滞的生理过程．一部分发生衰老的细胞会被机体自身清除，但另一些衰老的细胞会随着时间的推移在体内积累增多，并分泌一些免疫刺激因子，导致低水平炎症发生，引起周围组织衰老或癌变，这类具有特殊生物学特征和功能的细胞就是衰老细胞(senescent cell)．实验揭示，衰老细胞不仅是衰老过程的产物，也可能是组织器官进一步衰退的重要原因．近日，Baker等的一项研究成果(Nature，2011，479(7372)：232-236)表明，清除衰老细胞可延缓小鼠的衰老进程，该成果有望开辟出一条对抗衰老的新途径．
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| 关 键 词： | 细胞衰老，衰老细胞，p16Ink4a基因，AP20187，干细胞 |
| 收稿时间： | 1/8/2012 12:00:00 AM |
| 修稿时间： | 2012/2/27 0:00:00 |
Cellular Senescence and Senescent Cell |
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| WANG Pu,CHEN Lu-Ping,LI Qing-Quan,TANG Qi-Sheng,SHEN Yi-Wen and ZHU Jian-Hong.Cellular Senescence and Senescent Cell[J].Progress In Biochemistry and Biophysics,2012,39(3):257-263. |
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| Authors: | WANG Pu CHEN Lu-Ping LI Qing-Quan TANG Qi-Sheng SHEN Yi-Wen and ZHU Jian-Hong |
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| Institution: | 1,2,3,4)(1) Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai 200040,China; 2) State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China; 3) Institutes of Brain Science,Fudan University,Shanghai 200032,China; 4) Shanghai Medical College of Fudan University,Shanghai 200032,China) |
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| Abstract: | Cellular senescence is a process that leads to a growth arrest. Some of these cells are cleared after being in a state of alive but lose the ability to divided long time, while some cells (named senescent cell) accumulate in aging tissues, secrete agents that stimulate the immune system and cause low-level inflammation, which may disrupt nearby tissue structure and function even promote cancer progression. A recent report in Nature by Baker et al. introduced a method of delaying aging process by clearing senescent cells in mice. The findings raise the prospect that any therapy that rids the body of senescent cells would protect it from the ravages of aging. |
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| Keywords: | senescent cell cellular senescence p16Ink4a AP20187 stem cell |
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