The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays |
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| Authors: | Yevhen Vainshtein Mayka Sanchez Alvis Brazma Matthias W Hentze Thomas Dandekar Martina U Muckenthaler |
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| Affiliation: | (1) MMPU, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D-69120 Heidelberg, Germany;(2) European Molecular Biology Laboratory, D-69117 Heidelberg, Germany;(3) Department of Bioinformatics, University of Wurzburg, Biozentrum, Am Hubland, D-97074 Wurzburg, Germany;(4) IMPPC, Institute of Predictive and Personalized Medicine of Cancer, Crta Can Ruti, Cami de les Escoles s/n 08916 Badalona, Barcelona, Spain;(5) European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK |
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| Abstract: | Background Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However,
the complexity of array design, production and manipulations are limiting factors, affecting data quality. The use of customized
DNA microarrays improves overall data quality in many situations, however, only if for these specifically designed microarrays
analysis tools are available. |
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