Immunotoxic effects of nickel in the mud crab Scylla serrata |
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| Authors: | K Vijayavel S Gopalakrishnan R Thiagarajan H Thilagam |
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| Institution: | 1. Institute for Ocean Management, Koodal Building, Anna University, Chennai 600 025, Tamil Nadu, India;2. Department of Zoology, University of Madras, Chennai 600 025, Tamil Nadu, India;3. Department of Bio-Technology, Prince Venkateswara College of Arts and Science, Chennai 601 302, Tamil Nadu, India;1. Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Engineering Research Center of Agriculture, Shanghai Ocean University, 999 Huchenghuan Road, Lingang NewDistrict, Shanghai 201306, China;2. Xichang College, Xichang 415000, Sichuan Province, China;1. Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, Canada;2. Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, SK, Canada;1. School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand;2. Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand |
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| Abstract: | The presence of xenobiotic contaminants especially metals in coastal waters is a major concern as they are immunotoxic to aquatic animals even at low concentrations. In our present study, mud crab Scylla serrata was exposed to three sublethal concentrations (0.4, 0.6 and 0.8 mg/L) of nickel for 30 days under laboratory conditions and the alterations of hematological parameters like haemocyte count, clotting time, haemocyte viability, protein content and immunomodulatory components like phenoloxidase, phagocytosis and superoxide anion generation were measured. In addition, the accumulation patterns of nickel were measured in gills, hepatopancreas and ovary. The accumulation was more in gills when compared to hepatopancreas and ovary of crabs exposed to nickel and was not detected in the control crabs. The results revealed a significant (P < 0.05) induction of superoxide anion generation and phagocytosis activity in the haemolymph of the crabs exposed to nickel when compared to control. On the contrary, the rest of the parameters were significantly (P < 0.05) reduced in the experimental groups when compared to the control. All the studied parameters exhibited a concentration dependent response. |
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