| 多形核白细胞(PMN)引起鼠缺血心脏产生活性氧自由基的研究 |
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| 引用本文： | 赵保路,忻文娟,于玲范,夏德义.多形核白细胞(PMN)引起鼠缺血心脏产生活性氧自由基的研究[J].生物物理学报,1990,6(1):54-58. |
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| 作者姓名： | 赵保路 忻文娟 于玲范 夏德义 |
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| 作者单位： | 中国科学院生物物理研究所
(赵保路，忻文娟)，哈尔滨医科大学克山痞研究所
(于玲范)，哈尔滨医科大学克山痞研究所(夏德义) |
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| 摘 要： | 本文用电子(?)磁共振(ESR)在低温条件下直接研究了由维生素D_3(V_(D3))过量所致大白鼠心肌缺血损伤时血液中多形核白细胞(PMN)产生的活性氧自由基.实验结果发现,过量VD_3造成缺血损伤心肌中氧自由基含量比正常心肌增加了43%,比用10ml生理盐水冲洗的正常心肌增加了73%,比用过量V_(D3)造成心肌缺血损伤再用10ml生理盐水和冲洗的心肌增加了65%.这就说明,PMN在心肌缺血过程中对产生活性氧自由基起着主要作用.
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ESR STUDIES ON PRODUCTION OF ACTIVE OXYGEN FREE RADICALS EN ISCHEMIC MYOCARDIUM BY POLYMORPHONUCLEAR LEUKOCYTE |
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| Abstract: | The active oxygen free radicals produced by polymophonuclear leukocytes (PMN) in ischemic myocardium induced by over vitamine D3 (VD) were studied with electron spin resonance (ESR). It was found that the active oxygen free radicals were about 43% more in ischemic myocardium induced by VD than those in normal myocardium, and about 73% more than those in the normal myocardium washed with 10ml normal saline, and about 65% more than those in the ischemic myocardium induced by VD3 and washed with 10ml normal saline. This indicated that PMN played a key rule in production of active oxygen free radicals in ischemic myocardium. |
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