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Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa |
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| Authors: | Waffo Alain F Kamdem Coombes Philip H Crouch Neil R Mulholland Dulcie A El Amin Sawsan M M Smith Peter J |
| Institution: | School of Chemistry, University of KwaZulu-Natal, Howard College Campus, 4041, Durban, South Africa. |
| Abstract: | The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively. |
| Keywords: | Teclea gerrardii Rutaceae Stem bark Acridone alkaloids Furoquinoline alkaloids 3-Hydroxy-1-methoxy-N-methylacridone (tegerrardin A) 3-Hydroxy-N-methyl-1-(γ γ-dimethylallyloxy)acridone (tegerrardin B) Arborinine Evoxanthine 1 3-Dimethoxy-N-methylacridone Evoxine 7-(γ γ-Dimethylallyloxy)-γ-fagarine Tecleanone Plasmodium falciparum Antiplasmodial activity |
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