Telomeres: the molecular events driving end-to-end fusions |
| |
| Authors: | Bertuch Alison A |
| |
| Affiliation: | Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. abertuch@bcm.tmc.edu |
| |
| Abstract: | 
Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
