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The type II secretion system: biogenesis, molecular architecture and mechanism
Authors:Korotkov Konstantin V  Sandkvist Maria  Hol Wim G J
Affiliation:Department of Biochemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA.
Abstract:Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action.
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