The type II secretion system: biogenesis, molecular architecture and mechanism |
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Authors: | Korotkov Konstantin V Sandkvist Maria Hol Wim G J |
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Affiliation: | Department of Biochemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA. |
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Abstract: | Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action. |
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