DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR |
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| Authors: | Daniela Muhl Nadja Jeßberger Kristin Hasselt Christophe Jardin Heinrich Sticht Andreas Burkovski |
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| Affiliation: | 1. Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universit?t Erlangen-Nürnberg, Erlangen, Germany
2. Institut für Biochemie, Friedrich-Alexander-Universit?t Erlangen-Nürnberg, Erlangen, Germany
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| Abstract: | Background The TetR family member AmtR is the central regulator of nitrogen starvation response in Corynebacterium glutamicum. While the AmtR regulon was physiologically characterized in great detail up to now, mechanistic questions of AmtR binding were not addressed. This study presents a characterization of functionally important amino acids in the DNA binding domain of AmtR and of crucial nucleotides in the AmtR recognition motif. |
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