Corticotropin-releasing factor inhibits gastric emptying in dogs |
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Authors: | T Pappas H Debas Y Taché |
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Institution: | Center for Ulcer Research and Education, VA Wadsworth Medical Center, University of California, Los Angeles, CA 90073, U.S.A. |
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Abstract: | The purpose of the present study was to evaluate the effect of ovine corticotropin-releasing factor (CRF) on the gastric emptying of a saline meal in conscious dogs. Intravenous infusion of CRF (220-880 pmol . kg-1 . h-1), induced a significant linear dose dependent inhibition of gastric emptying (16-71%). CRF action was not modified by naloxone and not associated with vomiting or other side effects. Intravenous infusion of sulfated cholecystokinin octapeptide (CCK-8, 50-200 pmol . kg-1 . h-1) inhibited gastric emptying by 29-52%. The relative potency of CRF with respect to CCK-8 is 4 times less. These studies demonstrated that CRF given intravenously in picomolar amount inhibits gastric emptying of a liquid meal in dogs through a mechanism unrelated to opiates. The role of endogenous CRF in stress-induced inhibition of gastric emptying needs to be investigated. |
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Keywords: | corticotropin-releasing factor cholecystokinin naloxone gastric emptying dogs |
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