IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork

Authors:	Anne-Hélène Pillet Virginie Pasquier Jacques Thèze

Institution:	Institut Pasteur, Département Infection et Epidémiologie, Département d'Immunologie, Unité d'Immunogénétique Cellulaire, F-75015 Paris, France

Abstract:

Keywords:	IL interleukin Jak Janus kinase FRET Fö rster fluorescence resonance energy transfer mAb monoclonal antibody FCS fluorescence autocorrelated spectroscopy FCCS fluorescence cross-correlated spectroscopy GFP green fluorescent protein ECFP enhanced cyan fluorescent protein EYFP enhanced yellow fluorescent protein ROI region(s) of interest PFA paraformaldehyde TM transmembrane ACF autocorrelation function 3D three-dimensional 2D two-dimensional CCF cross-correlation function IL-2b biotinylated IL-2 SA streptavidin AlexaFluor mAbb biotinylated monoclonal antibodies CytD cytochalasin D COase cholesterol oxidase SMase sphingomyelinase DRM detergent-resistant membrane MD molecular dynamics PBS phosphate-buffered saline Rh6G Rhodamine-6G TBS Tris-buffered saline PDB Protein Data Bank
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