Residue-Resolved Stability of Full-Consensus Ankyrin Repeat Proteins Probed by NMR |
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| Authors: | Svava K. Wetzel,Christina Ewald,Giovanni Settanni,Andreas Plü ckthun,Oliver Zerbe |
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| Affiliation: | 1 Institute of Biochemistry, University of Zürich, CH-8057 Zürich, Switzerland2 Institute of Organic Chemistry, University of Zürich, CH-8057 Zürich, Switzerland3 MRC Centre for Protein Engineering, Cambridge CB2 0QH, UK |
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| Abstract: | |
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| Keywords: | DARPin, designed ankyrin repeat protein AR, ankyrin repeat MD, molecular dynamics H/D, hydrogen/deuterium MEXICO, measurement of fast proton exchange rates in isotopically labeled compounds PRE, paramagnetic relaxation enhancement HSQC, heteronuclear single quantum coherence NOE, nuclear Overhauser enhancement MTSL, 1-oxyl-2,2,5,5-tetramethyl-Δ3-pyrroline-3-methyl)mercaptyl MalNEt, N-ethyl-maleimide PF, protection factor |
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