| SARS-CoV-2入侵细胞的研究进展 |
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| 引用本文： | 乔嘉璐,彭倩,翟莹,李卫玲,孙宾莲.SARS-CoV-2入侵细胞的研究进展[J].病毒学报,2021,37(2):415-421. |
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| 作者姓名： | 乔嘉璐 彭倩 翟莹 李卫玲 孙宾莲 |
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| 作者单位： | 江汉大学医学院,江汉大学武汉生物医学研究院,武汉430056 |
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| 基金项目： | 国家自然科学基金面上项目(项目号:31670167),题目:HIV-1诱导miRNA210拮抗APOBEC3F的分子机制研究~~。 |
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| 摘 要： | 新型冠状病毒(SARS-CoV-2)感染引发的肺炎疫情已蔓延全球,尽快认清病毒感染规律和致病机制是做好疫情防控的基础。SARS-CoV-2表面的刺突蛋白(Spike,S)识别靶细胞受体并与之结合,诱导病毒与细胞的膜融合,是病毒侵入宿主细胞的第一步,也是预防和治疗病毒感染的关键靶点。大量研究揭示了病毒进入细胞的分子机制,本文将主要对SARS-CoV-2入侵细胞的研究成果进行总结,并简要叙述以该环节为靶点的药物和疫苗研发现状。
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| 关 键 词： | 新型冠状病毒(SARS-CoV-2) 病毒入侵 刺突蛋白 细胞受体 |
Research Progress on the Mechanism of SARS-CoV-2 Invading Cells |
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| QIAO Jialu,PENG Qian,ZHAI Ying,LI Weiling,SUN Binlian.Research Progress on the Mechanism of SARS-CoV-2 Invading Cells[J].Chinese Journal of Virology,2021,37(2):415-421. |
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| Authors: | QIAO Jialu PENG Qian ZHAI Ying LI Weiling SUN Binlian |
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| Institution: | (Wuhan Institute of Biomedical Sciences,School of Medicine,Jianghan University,Wuhan 430056,China) |
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| Abstract: | The pneumonia epidemic caused by infection of SARS-CoV-2 has spread all over the world.To prevent and control the epidemic,it is necessary to recognize the virus infection rules and pathogenic mechanisms.The spike protein on the surface of SARS-CoV-2 binds to the target cell receptor and participates in the fusion of the virus with cell membrane.This is the first step for the virus to invade the host cells and is also the key to develop strategies for preventing and tackling viral infections.A lot of studies have revealed the molecular mechanism about virus entry into cells.This review mainly summarized the research results of SARS-CoV-2 invading cells and briefly described the current status of drug and vaccine development. |
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| Keywords: | SARS-CoV-2 Virus invasion Spike protein Cell receptor |
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