1. Institutes of Molecular Medicine and Experimental Immunology, Rheinische Friedrich-Wilhelms-Universität, 53105 Bonn, Germany;2. Genomics and Immunoregulation, LIMES Institute, Rheinische Friedrich-Wilhelms-Universität, 53105 Bonn, Germany;3. Molecular Immunology, LIMES Institute, Rheinische Friedrich-Wilhelms-Universität, 53105 Bonn, Germany;4. Institute of Microbiology and Hygiene, Technische Universität München, 81675 München, Germany;5. Institute of Molecular Immunology, Technische Universität München, 81675 München, Germany;6. Department of Medicine 1, Universitätsklinikum Erlangen, 91054 Erlangen, Germany;7. Institute for Immunology, Johannes Gutenberg-Universität, 55122 Mainz, Germany;8. INSERM U1013 and Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
Abstract:
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Highlights? Memory-like CD8+ T cells are generated in the liver in the absence of inflammation ? An alternative pathway of T cell priming is facilitated by nonimmune cells ? Liver-primed T cells are rescued from deletion for anti-infectious immunity ? T cell priming in the liver complements conventional memory T cell generation
