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c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

Authors:	Denny L Cottle Kai Kretzschmar Pawel J Schweiger Sven R Quist Harald P Gollnick Ken Natsuga Satoru Aoyagi Fiona M Watt

Institution:	1. Wellcome Trust-Medical Research Council Stem Cell Institute (SCI), University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK;2. Clinic of Dermatology and Venereology, Otto-von-Guericke University, Magdeburg, Leipziger Str. 44, DE-39120 Magdeburg, Germany;3. Department of Dermatology, Hokkaido University School of Medicine, North 15 West 7, Sapporo 060-8638, Japan;4. Cancer Research UK Cambridge Research Institute (CRI), Li Ka Shing Centre, Cambridge CB2 0RE, UK

Abstract:	Download : Download full-size image Highlights? Myc-induced sebaceous differentiation depends on the androgen receptor and p53 ? The androgen receptor promotes sebocyte differentiation ? Myc induces a p53 response that promotes sebocyte proliferation ? p53 and the androgen receptor are mutually antagonistic

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