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Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor
Authors:Hisham Mohammed  Clive D’Santos  Aurelien A Serandour  H Raza Ali  Gordon D Brown  Alan Atkins  Oscar M Rueda  Kelly A Holmes  Vasiliki Theodorou  Jessica LL Robinson  Wilbert Zwart  Amel Saadi  Caryn S Ross-Innes  Suet-Feung Chin  Suraj Menon  John Stingl  Carlo Palmieri  Carlos Caldas  Jason S Carroll
Institution:1. Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK;2. Proteomic Core Facility, Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK;3. Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK;4. Thermo Fisher Scientific, Boundary Way, Hemel Hempstead HP2 7GE, UK;5. Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands;6. Department of Oncology, University of Cambridge, Cambridge CB2 0XZ, UK;7. Imperial College Healthcare NHS Trust, London W12 0NN, UK;8. Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
Abstract:
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  • Highlights? A proteomic method identifies protein-protein interaction in primary tumors ? GREB1 is the top estrogen-induced ER-interacting protein ? GREB1 is an essential ER cofactor recruited to chromatin ? GREB1 is an independent prognostic marker
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