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Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy
Authors:Mandy   S. Wong,Ling Chen,Christopher Foster,Radhika Kainthla,Jerry   W. Shay,Woodring   E. Wright
Affiliation:1. Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, USA;2. Sierra Sciences, Reno, NV 89502, USA
Abstract:
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  • Highlights? Alternative splicing is a new target for telomerase inhibition/activation ? Elements deep within introns regulate human telomerase splicing ? These intronic elements contain both unusual short repeats and direct repeats ? A direct-repeat oligonucleotide modifies splicing of endogenous telomerase
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