Epiblast origin and early migration of neural crest cells in the chick embryo |
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Authors: | Glenn C. Rosenquist |
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Affiliation: | Children''s Hospital National Medical Center, 111 Michigan Avenue NW, Washington, D. C. 20010 USA |
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Abstract: | Chick embryos carrying transplants labeled with tritiated thymidine demonstrate that the neural crest originates in the anterior epiblast, at the junction of areas destined for epidermis and neural tube. As the neural tube begins to fold and the axis lengthens, cells along this junction are drawn dorsomedially; at the seven-somite stage they begin to separate from the epithelium of the head, and migrate into the angle between the epidermis and the neural tube. The paraxial mesoderm already populating this angle originates in more posterior and medial portions of the epiblast than do the neural crest cells; after invagination at the primitive streak, it migrates anterolaterally, ventral to the ectoderm layer, until it too is folded dorsomedially into the angle between the epidermis and the neural tube. |
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Keywords: | To whom correspondence should be addressed. |
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