Construction and comparative analysis of two-component system and metabolic network profile based phylogenetic trees

In this study, two-component system (TCS) gene profile and metabolic network gene profile based phylogenetic trees were constructed and compared to each other to evaluate the evolutionary relationship between the bacterial sensing system and metabolism. The gene profiles of the these systems suggested that bacteria employed different evolutionary strategies to optimize the two-component system and metabolic network. In addition, comparative analysis revealed that the TCS based tree showed better family grouping than the metabolic network based tree, which indicated that the TCS and metabolic network have been modified via self-evolution and recruitment methods, respectively.