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Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia |
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| Authors: | Jens Przybilla Lydia Hopp Michael Lübbert Markus Loeffler Joerg Galle |
| Affiliation: | 1. Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany;2. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany;3. Division of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany;4. German Cancer Consortium (DKTK), Freiburg, Germany;5. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany |
| Abstract: | |
| Keywords: | 5-aza-2'-deoxycytidine 5-azacytidine acute myeloid leukemia computational modeling Decitabine demethylation therapy DNA methylation DNMT inhibitors histone modification mathematical modeling |