| 溶血磷脂酸受体及其信号转导 |
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| 引用本文： | 马睿.溶血磷脂酸受体及其信号转导[J].生物化学与生物物理进展,2000,27(1):48-52. |
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| 作者姓名： | 马睿 |
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| 作者单位： | 中国协和医科大学阜外心血管病医院中国医学科学院心血管病研究所,北京,100037 |
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| 摘 要： | 溶血磷脂酸(lysophosphatidic acid,LPA)是一种类生长因子的脂类信号分子.在血栓形成过程中被激活的血小板可以产生LPA.自从证明LPA有胞外信号功能以后，许多新的生物活性又被不断发现.LPA最主要的作用是诱导各类细胞增殖.人们已经找到几种LPA受体cDNA克隆.LPA主要通过G蛋白偶联受体影响靶细胞功能，其信号转导系统包括已知的几条信号通路: 激活Gq从而激活磷脂酶C; 激活Gi从而抑制腺苷酸环化酶并激活MAPK级联通路; 激活G12/13从而激活Rho级联通路等.
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| 关 键 词： | 溶血磷脂酸，受体cDNA克隆，信号转导 |
| 收稿时间： | 1999/1/14 0:00:00 |
| 修稿时间： | : |
The Lysophosphatidic Acid Receptors and Signal Transduction |
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| MA Rui.The Lysophosphatidic Acid Receptors and Signal Transduction[J].Progress In Biochemistry and Biophysics,2000,27(1):48-52. |
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| Authors: | MA Rui |
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| Institution: | Cardiovascular Institute of The Chinese Academy of Medical Sciences & FuWai Cardiovascular Hospital of The Peking Union Medical College, Beijing 100037, China |
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| Abstract: | Lysophosphatidic acid(LPA) is a novel growth-factor-like lipid mediator. It can be released from stimulated platelets as a product of the blood-clotting process. The number and diversity of the known biological responses to LPA keep growing from many years ago when it was first found as an out-membrane messenger. The more important function of LPA is that it can induce proliferation of many types of cells. Several LPA receptor cDNA clones have been found. LPA influences target cells mainly by activating special G protein coupled receptors. The signal transduction system of LPA includes several known signal cascades: activating Gq to stimulate PLC; activating Gi to restrain adenylyl cyclase and stimulate MAPK cascade; and activating G12/13 to stimulate Rho cascade, etc. |
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| Keywords: | lysophosphatidic acid receptor cDNA cloning signal transduction |
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