Natriuretic peptides modify <Emphasis Type="Italic">Pseudomonas fluorescens</Emphasis> cytotoxicity by regulating cyclic nucleotides and modifying LPS structure |
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Authors: | Wilfried Veron Nicole Orange Marc GJ Feuilloley Olivier Lesouhaitier |
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Institution: | (1) Laboratory of Cold Microbiology, UPRES EA 2123, University of Rouen, 55 rue Saint Germain, 27000 Evreux, France |
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Abstract: | Background Nervous tissues express various communication molecules including natriuretic peptides, i.e. Brain Natriuretic Peptide (BNP) and C-type Natriuretic Peptide (CNP). These molecules share structural similarities with
cyclic antibacterial peptides. CNP and to a lesser extent BNP can modify the cytotoxicity of the opportunistic pathogen Pseudomonas aeruginosa. The psychrotrophic environmental species Pseudomonas fluorescens also binds to and kills neurons and glial cells, cell types that both produce natriuretic peptides. In the present study,
we investigated the sensitivity of Pseudomonas fluorescens to natriuretic peptides and evaluated the distribution and variability of putative natriuretic peptide-dependent sensor systems
in the Pseudomonas genus. |
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