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Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics
Authors:Kelsey H. Fisher-Wellman  James A. Draper  Michael T. Davidson  Ashley S. Williams  Tara M. Narowski  Dorothy H. Slentz  Olga R. Ilkayeva  Robert D. Stevens  Gregory R. Wagner  Rami Najjar  Mathew D. Hirschey  J. Will Thompson  David P. Olson  Daniel P. Kelly  Timothy R. Koves  Paul A. Grimsrud  Deborah M. Muoio
Affiliation:1. Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA;2. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA;3. Duke Proteomics and Metabolomics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA;4. Cell Signaling Technologies, Danvers, MA 01923, USA;5. Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA;6. Department of Pediatrics, Division of Pediatric Endocrinology, Michigan Medicine, Ann Arbor, MI 48109, USA;7. Perelman School of Medicine, University of Pennsylvania, PA 19104, USA
Abstract:
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  • Keywords:mitochondrial diagnostics  lysine acylation  malonylation  ATP synthase
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