首页 | 本学科首页   官方微博 | 高级检索  
     


Sulfhydryl groups and the differentiation of murine erythroleukemia cells.
Authors:B Maresca  B M Jaffe  M G Santoro
Affiliation:1. Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, 4960 Audubon Avenue, St. Louis, Missouri, USA;2. the Department of Surgery, Washington University School of Medicine, 4960 Audubon Avenue, St. Louis, Missouri, USA
Abstract:The importance of cysteine and sulfhydryl groups has been demonstrated in relation to the differentiation and respiration of Friend erythroleukemia cells (FLC). The respiratory rate of undifferentiated FLC was higher basally (5.06 ± 0.16 vs. 3.10 ± 0.09 nmoles 02/min/106 cells) and was further 70% stimulated by addition of cysteine, whereas DMSO-induced differentiated cells were insensitive. A sulfhydryl blocking agent (PCMS) was capable of maintaining the differentiated state of FLC cultured in the absence of DMSO and this effect appeared to be reversible upon removal of the PCMS.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号