| 二维心室建模和Brugada综合症仿真 |
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| 引用本文： | 龚淑华,王宽全,袁永峰.二维心室建模和Brugada综合症仿真[J].现代生物医学进展,2007,7(10):1563-1565. |
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| 作者姓名： | 龚淑华 王宽全 袁永峰 |
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| 作者单位： | 哈尔滨工业大学计算机科学与技术学院生物信息技术中心,哈尔滨,150001 |
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| 基金项目： | 国家自然科学基金;国家高技术研究发展计划(863计划) |
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| 摘 要： | 本文以Tusscher提出的人体心室单细胞计算模型为基础,用计算机建模仿真的方法,构建一个心室壁组织的二维网格模型。通过修改细胞的离子通道参数,仿真了正常生理条件下和Brugada症状下三类心室细胞的动作电位和心电图波形。结果显示:Brugada症状下的心电图波形有明显的J波出现,ST-段抬高甚至T波倒置。这与临床医学上的报道基本符合,本研究为用计算机仿真建模研究Brugada综合症打下了基础。
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| 关 键 词： | 建模仿真 动作电位 离子通道 心电图 ST段抬高 Brugada综合症 |
| 文章编号： | 1673-6273（2007）10-1563-03 |
| 修稿时间： | 2007-04-30 |
A 2D Ventricular Modeling and Simulation of Brugada Syndrome |
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| GONG Shu-hua,WANG Kuan-quan,YUAN Yong-feng.A 2D Ventricular Modeling and Simulation of Brugada Syndrome[J].Progress in Modern Biomedicine,2007,7(10):1563-1565. |
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| Authors: | GONG Shu-hua WANG Kuan-quan YUAN Yong-feng |
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| Institution: | Biocomputing Research Center, the School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001 , Heilongfiang, China |
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| Abstract: | Based on the Tusscher's ventricular single cell mathematical model,a two-dimensional mesh ofventricular wall tis- sue was built using a method of computer modeling and simulation.Through the revision of the ion channel parameters of cells,the ac- tion potentials in three types ofventricular cells and the ECG waveforms were simulated under normal physiologic condition and Bruga- da syndrome.The results showed that the ECG waveforms under Brugada syndrome present ST-segment elevation with a pronounced J wave or even T-wave inversion.These are similar to the clinical findings reported in the literatures,which lays a good underlaying for us- ing computer modeling and simulation method in Brugada syndrome research. |
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| Keywords: | Modeling and simulation Action potential Ion channel ECG ST-segment elevation Brugada syndrome |
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