Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents |
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| Authors: | Kim Hye Yeon Lee Jae Seok Cha Joo Hwan Pae Ae Nim Cho Yong Seo Chang Moon Ho Koh Hun Yeong |
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| Affiliation: | Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, 130-650, Seoul, South Korea. hykoh@kist.re.kr |
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| Abstract: | We have prepared and evaluated the antibacterial activities of a series of substituted methylenepiperidinyl and methylenepyrrolidinyl oxazolidinones against several gram-positive strains including the resistant strains of Staphyloccus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed comparable or superior in vitro activities (MIC) to vancomycin. |
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