| 基于格子模型的蛋白质设计方法 |
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| 引用本文： | 刘赟,王存新,王宝翰,陈慰祖.基于格子模型的蛋白质设计方法[J].生物化学与生物物理进展,2004,31(2):172-176. |
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| 作者姓名： | 刘赟 王存新 王宝翰 陈慰祖 |
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| 作者单位： | 1. 北京工业大学生命科学与生物工程学院,北京,100022
2. 中国科学院生物物理研究所,北京,100101 |
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| 基金项目： | 国家自然科学基金（10174005，30170230）和北京市自然科学基金（5032002）资助项目. |
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| 摘 要： | 提出一个简单有效的蛋白质设计方法，这一方法完全基于物理学原理. 与同类工作相比，该方法在很大程度上可节省对序列空间进行的搜索，是对同类工作的简化与发展. 对三个平面格子模型进行的检验表明该方法是成功的. 该方法可进一步用于真实蛋白质的三维非格子模型.
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| 关 键 词： | 蛋白质设计，蛋白质逆折叠，格子模型，非格子模型 |
| 收稿时间： | 2003/8/18 0:00:00 |
| 修稿时间： | 2003/9/28 0:00:00 |
A Protein Design Procedure Based on The Lattice Model |
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| LIU Yun,WANG Cun-Xin,WANG Bao-Han and CHEN Wei-Zu.A Protein Design Procedure Based on The Lattice Model[J].Progress In Biochemistry and Biophysics,2004,31(2):172-176. |
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| Authors: | LIU Yun WANG Cun-Xin WANG Bao-Han and CHEN Wei-Zu |
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| Institution: | College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China;College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China;Institute of Biophysics, The Academy Sciences of China, Beijing 100101, China;College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China |
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| Abstract: | A new simple and effective approach completely based on the physical theory is proposed for protein design. Compared with the similar works, the algorithm saves a vast deal of trouble in exploring sequence space. The method is an improvement over previous works. The design procedure was tested on three lattice models in two dimensions and the successful results have been obtained. The method can be readily implemented for three-dimensional off-lattice models of real proteins. |
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| Keywords: | protein design inverse protein folding lattice model off-lattice model |
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