Selenium modifies carcinogen metabolism by inhibiting enzyme induction |
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| Authors: | Dipple Anthony Pigott Margaret A Milner John A |
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| Institution: | (1) LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, 21701 Frederick, MD;(2) Present address: Department of Food Science and, Division of Nutritional Sciences, University of Illinois, 455 Bevier Hall, 61801 Urbana, IL |
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| Abstract: | Since selenium has been found to exert a protective action against carcinogenesis in various systems, the mechanism where-by
sodium selenite inhibits DNA binding of the carcinogen, 7,12-dimethylbenza]anthracene, was investigated. It was found that
selenite preferentially reduced DNA binding occurring through ananti-dihydrodiol epoxide metabolite of this carcinogen by inhibiting the induction of an enzyme system that generates this specific
reactive metabolite. |
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| Keywords: | Selenium metabolism carcinogen metabolism modification of by selenium enzyme induction inhibition DNA binding inhibition of by sodium selenite antidihydrodiol epoxide metabolite glutathione peroxidase and selenium |
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