| 激活补体类乙型肝炎病毒表面抗原(HBsAg)循环免疫复合物在急慢性乙型肝炎中的意义 |
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| 引用本文： | 彭宣宪,方亮,谢天益,李兆瑞,李建生.激活补体类乙型肝炎病毒表面抗原(HBsAg)循环免疫复合物在急慢性乙型肝炎中的意义[J].病毒学报,1990(4). |
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| 作者姓名： | 彭宣宪 方亮 谢天益 李兆瑞 李建生 |
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| 作者单位： | 江西大学生物系微生物学教研室
(彭宣宪)，西安医科大学病毒学研究室
(方亮，谢天益)，西安市传染病医院
(李兆瑞)，西安市传染病医院(李建生) |
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| 摘 要： | 激活补体类HBsAg循环免疫复合物(HBsAg/C3-CIC )的检出率,与HBV复制标志的关系,在急慢性乙型肝炎病毒感染中表现不同。在慢性肝病(包括慢性迁延性乙型肝炎、慢性活动性乙型肝炎、乙型肝炎后肝硬化和HBV感染指标阳性的原发性肝癌)患者中,HBeAg阳性者,其HBsAg/C3-CIC的检出率显著高于HBeAg阴性者,且随HBeAgS/N值的升高而增加。在由HBV e系统组合成的四种模式中,单纯HBeAg阳性模式的检出率显著高于其它三种模式;在多聚白蛋白受体(PHSAr)阳性者中检出率显著高于PHSAr阴性者。而急性乙型肝炎(AH)的HBsAg/C3-CIC检出率无类似差异。这些结果提示,HBsAg/C3-CIC在HBV感染的急慢性肝病中具有不同的病理生理意义。
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| 关 键 词： | 乙型肝炎 循环免疫复合物 补体 |
SIGNIFICANCE OF CIRCULATING HEPATITIS B VIRAL SURFACE ANTIGEN ( HBsAg ) COMPLEMENT IN ACUTE AND CHRONIC HEPATITIS B INFECTIONS |
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| Peng Xuanxian Fang Liang Xie TianyiLi Zhaorui Li Jianshen Biology.SIGNIFICANCE OF CIRCULATING HEPATITIS B VIRAL SURFACE ANTIGEN ( HBsAg ) COMPLEMENT IN ACUTE AND CHRONIC HEPATITIS B INFECTIONS[J].Chinese Journal of Virology,1990(4). |
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| Authors: | Peng Xuanxian Fang Liang Xie TianyiLi Zhaorui Li Jianshen Biology |
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| Institution: | Peng Xuanxian Fang Liang Xie TianyiLi Zhaorui Li Jianshen Biology Department of Jiangxi University Virology Department of Xian Medical University Infection Hospital,Xian |
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| Abstract: | Chronic hepatitis B infection differs from acute hepatitis B infection in the relationship between the positive rates of HBsAg/C3-CIC and the markers of HBV reproduction. In chronic hepatitis B infection, the positive rates of HBsAg/C3-CIC in the HBeAg positive samples were significantly higher than in the HBeAg negative ones and rose in parallel to HBeAg S/N values. The HBsAg/C3-CIC positive rates among PHSAr positive cases were significantly higher than those in the PHSAr negative samples. In cases which were HBeAg-positive alone, the HBsAg/C3-CIC positive rates were significantly higher than those in other types of the HBV e system. This difference did not exist in acute hepatitis B cases. The results suggest that the pathological and physiological significance of HBsAg/C3-CIC in chronic hepatitis B virus infection may differ from that in acute hepatitis B virus infection. |
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| Keywords: | Hepatitis B Circulating immune complexes Complement |
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