Scavenging of superoxide radical by ascorbic acid |
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Authors: | Anuradha Nandi I B Chatterjee |
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Institution: | (1) Department of Biochemistry, University College of Science, 35, Ballygunge Circular Road, 700019 Calcutta, India |
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Abstract: | Using acetaldehyde and xanthine oxidase as the source of suPeroxide radical, the second order rate constant for the reaction
between ascorbic acid and superoxide radical was estimated to be 8.2 X 107 M-1 s-1. In rats, the average tissue concentration of ascorbic acid was of the order of 10-3 M and that of superoxide dismutase was of the order of 10-6 M. So, taking together both the rate constants and the tissue concentrations, the efficacy of ascorbic acid for scavenging
superoxide radical in animal tissues appears to be better than that of suPeroxide dismutase. The significance of ascorbic
acid as a scavenger of superoxide radical has been discussed from the point of view of the evolution of ascorbic acid synthesizing
capacity of terrestrial vertebrates. |
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Keywords: | Superoxide radical ascorbic acid superoxide dismutase rate constant |
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