Neuronal Development in Caenorhabditis elegans Is Regulated by Inhibition of an MLK MAP Kinase Pathway |
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| Authors: | Scott T. Baker Shane M. Turgeon Erik D. Tulgren Jeanne Wigant Omeed Rahimi Karla J. Opperman Brock Grill |
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| Affiliation: | *Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458;†Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455 |
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| Abstract: | We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway. |
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| Keywords: | JNK MAP kinase RPM-1 axon synapse |
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