Populations of follicles in F344/N rats during aging |
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| Authors: | Kazutoshi Nishijima Shin Tanaka Shinsuke H. Sakamoto Sachi Kuwahara Tamio Ohno Shuji Kitajima |
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| Affiliation: | 1. Division of Biological Resources and Development, Analysis Research Center for Experimental Sciences, Saga University, Saga, Japan;2. Formerly Animal Facility for Aging Research, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan;3. Department of Bio-resources, Division of Biotechnology, Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan;4. Department of Anatomy, Hyogo Collage of Medicine, Nishinomiya, Japan;5. Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Nagoya University, Nagoya, Japan;1. Livestock Department, Fukuoka Agricultural Research Center, Chikushino, Fukuoka, Japan;2. Pathology and Pathophysiology Research Division, National Institute of Animal Health, Tsukuba, Ibaraki, Japan;3. Department of Clinical Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto, Kagoshima, Japan;4. Department of Animal Science, Graduate School of Natural Science and Technology, Okayama University, Tsushima-naka, Okayama, Japan;5. Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan;6. Animal Breeding and Reproduction Research Division, National Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan;1. Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan;2. Department of Theriogenology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura 35516, Egypt;3. Japan Animal Referral Medical Center, Kanagawa 213-0032, Japan;4. Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan;5. Laboratory of Parasitic Diseases, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan;1. Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan;2. Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan;3. Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan;4. College of Pharmacology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan;5. Departments of Pharmacology, University of Iowa Carver, College of Medicine, Iowa City, IA 52242, USA;6. Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City, IA 52242, USA;7. United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;1. Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan;2. Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Shimotsuke, Tochigi, Japan;1. Department of Surgery 1, Fukushima Medical University, Fukushima, Japan;2. Institute of Advanced Biomedical Engineering and Science, Tokyo Women''s Medical University, Tokyo, Japan |
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| Abstract: | ![]()
Follicular populations were investigated in female F344/N rats to better understand the aging process of the rat ovary. Ovaries dissected at various ages (spanning 1–36 months old) were submitted for histological examination. The total number of primordial, growing (primary and secondary), tertiary, and atretic follicles as well as corpora lutea (CL) were counted in hematoxylin–eosin- and azocarmine–aniline-blue-stained ovarian sections. The number of healthy follicles including primordial, growing and tertiary follicles decreased rapidly between the first and third months and gradually thereafter. CL were found in 3-month-old rats, and their number remained unchanged until 18 months of age, at which point it decreased. The number of atretic follicles started to increase in rats older than 18 months, which corresponded to the cessation of estrous cyclicity. Several healthy follicles and CL were observed even in 36-month-old rats. |
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| Keywords: | Development Senescence Ovary Oocyte F344/N rats |
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