灵芝抗氧化清除自由基作用的研究

文中综述了灵芝的抗氧化清除自由基作用。灵芝对各种因素引起的脑、心脏、胰腺、肝脏、胃肠道、肾脏和其他重要脏器的脂质过氧化损伤具有明显的保护作用。灵芝可显著减少脂质过氧化产物丙二醛(MDA)的含量,增强抗氧化酶如超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)以及其他抗氧化酶的活性。稹灵芝对体外培养的巨噬细胞(小鼠)、胰岛细胞(小鼠)、大脑皮层细胞(大鼠)、嗜铬细胞瘤细胞(大鼠)、血管内皮细胞(大鼠、人)和皮肤角质细胞(人)的氧化损伤具有明显保护作用。灵芝在体内外对不同动物模型和细胞模型的抗氧化清除自由基作用可能与其免疫调节、抗肿瘤、降血压、降血糖、保肝、心血管保护和抗衰老作用的机制有关。

Study on Anti-Oxidative and Free Radical Scavenging Activity of Ganoderma lucidum

This article summarized the anti-oxidative effect and free radical scavenging activity of Ganoderma lucidum （Lingzhi）. Lingzhi has apparent protective effects against the lipid peroxidation caused by a variety of factors in brain, heart, pancreas, liver, gastrointestinal, kidney, and other vital organs. Lingzhi can significantly reduce the content of lipid peroxidation product such as malondial- dehyde （MDA） and lipofuscin, and can enhance the activities of antioxidative enzyme such as super- oxide dismutase （ SOD ）, glutathione peroxidase （ GSH - PX ）, and other antioxidative enzyme. In macrophages （ mouse ）, is let cells （ mouse ）, cerebral cortex cells （ rat ）, pheochromocytoma cells （ PC 12 ceils, rat）, vascular endothelial cells （ rat, human ）, keratinocytes （human） Lingzhi has sig- nificant protective effect against the oxidant-induced oxidative damage. Anti-oxidative effect and free radical scavenging activity of Ganoderma lucidum on different animal models in vivo and in vitro may be related to its pharmacological mechanism of immunomodulating, anti-tumor, anti-hypertensive, hypoglycemic, liver-protective, cardio-vascular protective and anti-aging effects.