In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes |
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| Authors: | Saito M Taylor G P Saito A Furukawa Y Usuku K Weber J N Osame M Bangham C R |
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| Affiliation: | Departments of Immunology, Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom. |
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| Abstract: | ![]()
Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo. |
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