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Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists |
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| Authors: | Dyck Brian Zhao Liren Tamiya Junko Pontillo Joseph Hudson Sarah Ching Brett Heise Christopher E Wen Jenny Norton Christi Madan Ajay Schwarz David Wade Warren Goodfellow Val S |
| Affiliation: | Department of Medicinal Chemistry, Neurocrine Biosciences Inc., San Diego, CA 92130, USA. bdyck@neurocrine.com |
| Abstract: | A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered. |
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