Neurofascin: a switch between neuronal plasticity and stability |
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| Authors: | Kriebel Martin Wuchter Jennifer Trinks Sabine Volkmer Hansjürgen |
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| Affiliation: | 1. Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;2. Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan;1. Neurolipid Biology, Instituto de Investigação e Inovação em Saúde da Universidade do Porto - i3S, Porto, Portugal;2. Instituto de Biologia Molecular e Celular – IBMC, Porto, Portugal;3. Neuronal Networks Group, Instituto de Investigação e Inovação em Saúde da Universidade do Porto - i3S, Porto, Portugal;1. Referral Centre for Neuromuscular Diseases and ALS, La Timone hospital, Marseille, France;2. Immunology Laboratory, La Conception Hospital, Marseille, France;3. Aix-Marseille University, Timone Neuroscience Institute, UMR CNRS 7289, 13005 Marseille, France;4. Institut de Neurosciences de Montpellier, Montpellier, France;5. Department of Neurology, Aston Medical School, Aston University, Birmingham, UK;6. Referral Centre for Peripheral Neuropathies, CHU Bicetre, APHP, Paris, France;7. Department of Neurology, Saint Etienne, France;8. Department of Neurology, Hôpital Foch, Paris, France;9. Department of Neurology, Toulouse, France;10. Department of Neurology, Reims, France;11. Department of Neurology, Montpellier, France;12. INSERM U1195, Paris-Sud University, Le Kremlin Bicêtre, France;13. Department of Neurology, INSERM U1119, Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France;14. Nerve Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland;15. Department of Nephrology, Brest, France;p. Department of Neurology, APHP, Hôpital Pitie Salpêtrière, France;q. Department of Neurology, Hôpital Erasme, Bruxelles, Belgium;r. Department of Neurology, Pointe A Pitre, France;s. Department of Clinical Neurophysiology, Amiens, France;t. Department of Neurology, Brest, France;u. Department of Neurology, Vannes, France;v. U1171, CHU de Lille, Centre de référence des maladies neuromusculaires Nord Est Ile de France, Department of Neurology, Lille, France;w. Department of Neurology, Limoges, France;1. Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, Colorado;2. Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado;3. Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado;4. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado;5. School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado;6. Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, Colorado;7. Institut Pasteur, Decision and Bayesian Computation, Centre National de la Recherche Scientifique (CNRS) UMR 3525, Paris, France;8. Physico-Chimie Curie, Institut Curie, Paris Sciences Lettres, CNRS UMR 168, Université Pierre et Marie Curie, Paris, France;9. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia;1. Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria, Australia;2. Australian Research Council, Centre of Excellence for Integrative Brain Function, Monash University Node, Melbourne, Victoria, Australia |
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| Abstract: | Neurofascin (NF) is a cell surface protein belonging to the immunoglobulin superfamily (IgSF). Different polypeptides of 186, 180, 166 and 155 kDa are generated by alternative splicing. Expression of these isoforms is temporally and spatially regulated and can be roughly grouped into embryonic, adult and glial expression. NF interacts with many different interaction partners both extra- and intracellularly. Interactions of NF166 and NF180 selectively regulate mechanisms of plasticity like neurite outgrowth and the formation postsynaptic components. By contrast, NF155 and NF186 confer stabilization of neural structures by interaction with voltage-gated sodium channels and ankyrinG at axon initial segments (AIS) or nodes of Ranvier as well as neuron-glia interactions at the paranodes. Alternatively spliced isoforms of neurofascin may therefore balance dynamic and stabilizing mechanisms of the CNS. |
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