Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum |
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| Authors: | Ori Kazutomo Koroda Minpei Mimaki Yoshihiro Sakagami Hiroshi Sashida Yutaka |
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| Institution: | Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
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| Abstract: | Three tetranorlanostane glycosides, named lucilianosides C-E, and three lanostane glycosides, named scillasaponins E-G, together with a known lanostane glycoside, were isolated from the MeOH extract of Muscari paradoxum (Liliaceae) bulbs, as confirmed by detailed analysis of their 1H, 13C, and two-dimensional NMR spectroscopic data, and by the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 human oral squamous cell carcinoma cells. |
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| Keywords: | Muscari paradoxum Liliaceae Tetranorlanostane glycosides Lucilianosides C-E Lanostane glycosides Scillasaponins E-G Cytotoxic activity HSC-2 cells |
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